Product Name	DLL1
Chinese Name	Notch信号通路Delta样配体1抗体
Alias	Delta (Drosophila) like 1; Delta; Delta like 1 (Drosophila); Delta like 1; Delta like 1 protein; Delta like protein 1; Delta like protein 1 precursor; Delta, Drosophila, homolog of 1; Delta-like protein 1; Delta1; DL1; DLL 1; Dll1; DLL1_HUMAN; Drosophila Delta homolog 1; H-Delta-1; OTTHUMP00000017690.
Research Area	Tumour  Cell biology  immunology  Stem cells  transcriptional regulatory factor  lymphocyte  b-lymphocyte  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	76kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DLL1: 1-100/723 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in adult heart and lung. Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Subunit: Interacts with Notch receptors. Subcellular Location: Membrane. Tissue Specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Similarity: Contains 1 DSL domain. Contains 8 EGF-like domains. SWISS: O00548 Gene ID: 28514 Database links: Entrez Gene: 28514 Human Entrez Gene: 13388 Mouse Entrez Gene: 84010 Rat Omim: 606582 Human SwissProt: O00548 Human SwissProt: Q61483 Mouse SwissProt: P97677 Rat Unigene: 379912 Human Unigene: 4875 Mouse Unigene: 10628 Rat
Product Picture	Sample:Heart (Mouse) Lysate at 40 ug Primary: Anti-DLL1(SL7345R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76kD Observed band size: 81kD

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