Product Name	CARD15/NOD2
Chinese Name	凋亡加强结构域蛋白15抗体
Alias	ACUG; Arthrocutaneouveal granulomatosis; BLAU; CARD15; Caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; CD; IBD1; Inflammatory bowel disease protein 1; LRR containing protein; LRR-containing protein; Nod2; NOD2 protein; NOD2_HUMAN; NOD2B; nucleotide binding oligomerization domain 2; nucleotide-binding oligomerization domain 2; Nucleotide-binding oligomerization domain-containing protein 2; PSORAS1.
literatures	Specific References  (1)     |     SL7084R has been referenced in 1 publications. [IF=6.208] Lan Yang. et al. Lactobacillusjohnsonii L531 Protects against Salmonella Infantis-Induced Intestinal Damage by Regulating the NOD Activation, Endoplasmic Reticulum Stress, and Autophagy. INT J MOL SCI. 2022 Jan;23(18):10395  WB ;  Pig, Human.   PubMed:36142312
Research Area	Cell biology  immunology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	114kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CARD15: 251-350/1040
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) . EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement. Subunit: Binds to RIPK2/RICK by CARD-CARD interaction. Subcellular Location: Cytoplasm. Tissue Specificity: Monocytes-specific. Similarity: Contains 2 CARD domains. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain. SWISS: Q9HC29 Gene ID: 64127 Database links: Entrez Gene: 64127 Human Entrez Gene: 257632 Mouse Entrez Gene: 291912 Rat Omim: 605956 Human SwissProt: Q9HC29 Human SwissProt: Q8K3Z0 Mouse Unigene: 592072 Human Unigene: 222633 Mouse Unigene: 218600 Rat CARD15与家族性肠黏膜克罗恩病有关。
Product Picture	Sample: A549(Human) Cell Lysate at 30 ug MCF-7(Human) Cell Lysate at 30 ug Primary: Anti-NOD2 (SL7084R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Sample: MCF-7(Human) Cell Lysate at 30 ug Primary: Anti-NOD2 (SL7084R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Blank control(blue): Raji(fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-CARD15/AF488 Conjugated antibody(SL7084R-/AF488 ), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF488(orange) ,used under the same conditions );

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