Product Name	BMP11
Chinese Name	骨形态发生蛋白11抗体
Alias	GDF11; BMP 11; Bone morphogenetic protein 11; GDF 11; Growth differentiation factor 11; Growth/differentiation factor 11; GDF11_HUMAN.
literatures	Specific References  (2)     |     SL7076R has been referenced in 2 publications. [IF=4.522] Wang Y et al. Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway. J Cell Physiol. 2019 Oct 21.  WB ;  Rat.   PubMed:31637734 [IF=2.728] Xijuan Liu et al. Chondrocyte suppression is mediated by miR‐129‐5p via GDF11/SMAD3 signaling in developmental dysplasia of the hip. J Orthop Res. 2020 Dec;38(12):2559-2572.  WB/IHC ;  Rabbit.   PubMed:32396235
Research Area	Cell biology  Neurobiology  Signal transduction  Growth factors and hormones  transcriptional regulatory factor  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Chicken, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12/43kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BMP11: 301-407/407
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]. Function: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Subunit: Homodimer; disulfide-linked. Subcellular Location: Secreted (Probable). Similarity: Belongs to the TGF-beta family. SWISS: O95390 Gene ID: 10220 Database links: Entrez Gene: 10220 Human Entrez Gene: 14561 Mouse Entrez Gene: 29454 Rat Omim: 603936 Human SwissProt: O95390 Human SwissProt: Q9Z1W4 Mouse SwissProt: Q9Z217 Rat Unigene: 600883 Human Unigene: 299218 Mouse Unigene: 51292 Rat
Product Picture	Sample: Muscle (Mouse) Lysate at 40 ug Primary: Anti-BMP11 (SL7076R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 12 kD Observed band size: 12 kD Paraformaldehyde-fixed, paraffin embedded (mouse skeletal muscle tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BMP11) Polyclonal Antibody, Unconjugated (SL7076R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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