Product Name	phospho-PBP (Ser153)
Chinese Name	磷酸化Raf激酶抑制蛋白抗体
Alias	PBP (phospho S153); p-PBP (phospho S153); p-RKIP (S153); p-RKIP (Ser153); RKIP (phospho-Ser153); RKIP (phospho-S153); phosphatidylethanolamine-binding protein; PEBP; PBP; Phosphatidylethanolamine-binding protein 1; PEBP-1; PEBP1; Prostatic-binding protein; Prostatic binding protein; Neuropolypeptide h3; HCNPpp; Raf kinase inhibitor protein; Hippocampal cholinergic neurostimulating peptide; HCNP; PEBP1_HUMAN.
literatures	Specific References  (1)     |     SL7075R has been referenced in 1 publications. [IF=6.208] Viviana Tritto. et al. Changes of RAS Pathway Phosphorylation in Lymphoblastoid Cell Lines from Noonan Syndrome Patients Carrying Hypomorphic Variants in Two NS Genes. INT J MOL SCI. 2023 Jan;24(4):4035  WB ;  Human.   PubMed:36835447
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  Signal transduction  Apoptosis  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human RKIP around the phosphorylation site of Ser153: VA(p-S)FR
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Subunit: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Subcellular Location: Cytoplasm. Similarity: Belongs to the phosphatidylethanolamine-binding protein family. SWISS: P30086 Gene ID: 5037 Database links: Entrez Gene: 5037 Human Entrez Gene: 29542 Rat Omim: 604591 Human SwissProt: P30086 Human SwissProt: P31044 Rat Unigene: 433863 Human Unigene: 29745 Rat Raf激酶抑制蛋白(PKIP)属于磷脂酰乙醇胺Binding protein（phosphatidylethanolamine-binding protein, PEBP）家族,广泛存在于各种不同的生物中,PKIP还参与了对NF-kB信号通路和G protein-coupled receptor信号通路的调控,参与NF-κB信号通路的调控,参与了对细胞内多种Signal transduction通路的调节作用。RKIP在膜的生物合成、精子发生、神经发育和Apoptosis等生理过程中发挥重要作用，并参与了老年痴呆症及Diabetes等的病理过程。有学者认为：RKIP有抑制Tumour细胞转移的作用。

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