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Product Name Glucokinase regulatory protein Chinese Name 葡萄糖激酶调节蛋白抗体 Alias FGQTL5; GCKR; GCKR_HUMAN; GKRP; GLRE; glucokinase (hexokinase 4) regulator; Glucokinase regulator; Glucokinase regulatory protein; OTTHUMP00000158533. Research Area Tumour Cardiovascular Cell biology Signal transduction transcriptional regulatory factor Diabetes Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 69kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GCKR: 121-220/625 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Inhibits glucokinase by forming an inactive complex with this enzyme.
Tissue Specificity:
Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
Similarity:
Belongs to the GCKR family.
Contains 2 SIS domains.
SWISS:
Q14397
Gene ID:
2646
Database links:Entrez Gene: 2646 Human
Entrez Gene: 231103 Mouse
Omim: 600842 Human
SwissProt: Q14397 Human
SwissProt: Q91X44 Mouse
Unigene: 89771 Human
Unigene: 100043 Mouse
Product Picture Tissue/cell: rat liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GCKR/Glucokinase regulatory protein Polyclonal Antibody, Unconjugated (SL7057R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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