Product Name	DENTT
Chinese Name	细胞分裂核仁蛋白1抗体
Alias	CASK interacting nucleosome assembly protein; CINAP; CDA1; Cell division autoantigen 1 nucleolar protein; CTCL tumor antigen se20-4; DENTT; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; TSPY-like 2; TSPY-like protein 2; Tspyl2; Testis-specific Y-encoded-like protein 2; Cutaneous T-cell lymphoma-associated antigen se20-4; SE20 4; SE204; CTCL-associated antigen se20-4; NP79; TSYL2_HUMAN.
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	76kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DENTT: 251-350/693
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CASK interacting nucleosome assembly protein (CINAP) modulates gene expression and its abundance in cultured neurons is regulated by synaptic activity. CINAP is widely expressed in different regions of adult mouse brain, including the cerebral cortex, hippocampus, striatum, hypothalamus, cerebellum, and two adult brain regions known to generate progenitor neurons. During early development, CINAP is also expressed in regions where neuronal progenitor cells are actively dividing, the ventricular and subventricular zones, suggesting that in addition to regulating gene expression in mature neurons CINAP may also play a role in dividing cells. Function: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Subunit: Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2. Subcellular Location: Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons. Tissue Specificity: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. Post-translational modifications: Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable). Similarity: Belongs to the nucleosome assembly protein (NAP) family. SWISS: Q9H2G4 Gene ID: 64061 Database links: Entrez Gene: 64061 Human Entrez Gene: 52808 Mouse Entrez Gene: 302612 Rat Omim: 300564 Human SwissProt: Q9H2G4 Human SwissProt: Q7TQI8 Mouse Unigene: 136164 Human Unigene: 592916 Human Unigene: 9997 Mouse
Product Picture	Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (DENTT) polyclonal Antibody, Unconjugated (SL7051R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

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