Product Name	CLCN3
Chinese Name	氯离子Channel protein3抗体
Alias	Chloride channel 3; Chloride channel protein 3; Chloride transporter ClC 3; Chloride transporter ClC-3; Chloride transporter ClC3; ClC 3; ClC-3; ClC3; CLCN 3; CLCN3; CLCN3_HUMAN; H(+)/Cl(-) exchange transporter 3.
literatures	Specific References  (2)     |     SL6981R has been referenced in 2 publications. [IF=3.454] Blair HC et al. Support of Bone Mineral Deposition by Regulation of pH.Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C587-C597.  IHF ;  Mouse.   PubMed:30044661 [IF=0] Larrouture, Quitterie C., et al. "Chloride–hydrogen antiporters ClC‐3 and ClC‐5 drive osteoblast mineralization and regulate fine‐structure bone patterning in vitro." Physiological Reports 3.11 (2015): e12607.  WB ;  Human.   PubMed:26603451
Research Area	Cell biology  Neurobiology  Signal transduction  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	91kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLCN3/CLC-3: 81-180/818
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Function: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Subunit: Homo- or heterodimer. Isoform 2 interacts with GOPC, PDZK1 and SLC9A3R1/EBP50. Subcellular Location: Isoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Isoform 2: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Tissue Specificity: Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). Post-translational modifications: N-glycosylated. Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. Contains 2 CBS domains. SWISS: P51790 Gene ID: 1182 Database links: Entrez Gene: 1182 Human Entrez Gene: 12725 Mouse Entrez Gene: 84360 Rat Omim: 600580 Human SwissProt: P51790 Human SwissProt: P51791 Mouse SwissProt: P51792 Rat Unigene: 481186 Human Unigene: 25263 Mouse Unigene: 259751 Mouse Unigene: 4175 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CLCN3) Polyclonal Antibody, Unconjugated (SL6981R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CLCN3/CLC-3 Polyclonal Antibody, Unconjugated(SL6981R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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