Product Name	ASMTY
Chinese Name	松果体N甲基乙酰羟色胺抗体
Alias	acetylserotonin methyltransferase (Y chromosome); acetylserotonin N-methyltransferase; Acetylserotonin O-methyltransferase; ASMT; ASMTY; HIOM_HUMAN; HIOMT; HIOMTY; Hydroxyindole O-methyltransferase.
literatures	Specific References  (6)     |     SL6961R has been referenced in 6 publications. [IF=5.249] Zhang, WL.. et al. Expression of arylalkylamine n-acetyltransferase (AANAT) and acetylserotonin o-methyltransferase (ASMT) in the corpus luteum of pregnant sows and synthesis of melatonin in luteal cells. 2021 Nov 24  WB,IHC ;  Pig.   PubMed:34816281 [IF=3.24] Herman, A. P., et al. "Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin." Mediators of Inflammation 2016 (2016).  WB ;  Others.   PubMed:27212805 [IF=2.71] Herman, A. P., et al. "Interleukin-1β Modulates Melatonin Secretion in Ovine Pineal Gland: Ex Vivo Study." BioMed Research International (2015).  WB ;  Other Species.   PubMed:26339621 [IF=2.089] Huawei Wei. et al. Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells. REPROD BIOL. 2022 Dec;22:100677  WB, IHC ;  Dog.   PubMed:36152357 [IF=1.858] Wenbo Ge. et al. Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro. REPROD DOMEST ANIM. 2022 Aug;:  IHC ;  Sheep.   PubMed:36018566 [IF=0.86] Herman et al. Endotoxin-induced inflammation disturbs melatonin secretion in ewe. (2017) Asian-Australas.J.Anim.Sci. 30:1784-1795  WB ;  Sheep.   PubMed:28728370
Research Area	Cell biology  immunology  Neurobiology  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Dopamine transporter: 241-345/345
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Most abundant in pineal gland, less in retina and brain, not in pigment epithelium. Function: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Tissue Specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). Similarity: Belongs to the methyltransferase superfamily. SWISS: P46597 Gene ID: 438 Database links: UniProtKB/Swiss-Prot: P46597.1
Product Picture	Sample: Brain (Rat) Lysate at 40 ug Primary: Anti- ASMTY (SL6961R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 38 kD Observed band size: 38/45 kD

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