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Product Name SIK2 Chinese Name 丝氨酸/苏氨酸蛋白激酶SIK2抗体 Alias QIK; Qin induced kinase; Qin-induced kinase; Salt inducible kinase 2; Salt inducible protein kinase 2; Salt inducible serine/threonine kinase 2; Salt-inducible protein kinase 2; Serine/threonine protein kinase SIK2; Serine/threonine protein kinase SNF1 like kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK 2; SIK-2; ; SIK2_HUMAN; SNF1 like kinase; SNF1 like kinase 2; SNF1LK2; DKFZp434K1115; EC 2.7.11.1; KIAA0781; LOH11CR1I. literatures Specific References (1) | SL6930R has been referenced in 1 publications.[IF=2.248] Wei Shunying. et al. Overexpression of circ_CELSR1 facilitates paclitaxel resistance of ovarian cancer by regulating miR-149-5p/SIK2 axis. Anti-Cancer Drug. 2021 Jun;32(5):496-507 WB ; Human.Research Area Tumour Cell biology Neurobiology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 104kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SNF1LK2/SIK2: 281-380/926 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Subunit:
Interacts with and phosphorylates TORC2/CRTC2.
Subcellular Location:
Cytoplasm
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Contains 1 protein kinase domain.
Contains 1 UBA domain.
SWISS:
Q9H0K1
Gene ID:
23235
Database links:Entrez Gene: 23235 Human
Entrez Gene: 235344 Mouse
Omim: 608973 Human
SwissProt: Q9H0K1 Human
SwissProt: Q8CFH6 Mouse
Unigene: 269128 Human
Unigene: 104932 Mouse
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