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Product Name STK40 Chinese Name 丝氨酸/苏氨酸蛋白激酶40抗体 Alias Ser/Thr like kinase; Serine/threonine kinase 40; Serine/threonine protein kinase 40; SgK495; SHIK; SINK homologous serine/threonine protein kinase; SINK-homologous serine/threonine-protein kinase; STK 40; Sugen kinase 495; STK40_HUMAN. Research Area Cell biology Signal transduction Cyclin transcriptional regulatory factor Kinases and Phosphatases Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human STK40: 231-330/435 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail STK40 may be a negative regulator of NF-kappa-B and p53-mediated gene transcription. There are four named isoforms.
Function:
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
Subcellular Location:
Cytoplasmic and Nuclear.
Tissue Specificity:
Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
SWISS:
Q8N2I9
Gene ID:
83931
Database links:
UniProtKB/Swiss-Prot: Q8N2I9.2
Product Picture Sample: Heart (Mouse) Lysate at 40 ug
Primary: Anti-STK40 (SL6899R) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution
Predicted band size: 48 kD
Observed band size: 48 kD
Sample:
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti- STK40 (SL6899R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48 kD
Observed band size: 49 kD
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (STK40) Polyclonal Antibody, Unconjugated (SL6899R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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