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Product Name Nucleostemin Chinese Name 核Stem cells因子鸟嘌呤核苷酸Binding protein3抗体 Alias E2 induced gene 3 protein; E2IG3; Estradiol induced nucleotide binding protein; GNL3; Guanine nucleotide binding protein like 3 (nucleolar); Guanine nucleotide binding protein like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP binding protein 3; Nucleostemin; Putative nucleotide binding protein estradiol induced; C77032; GNL3_HUMAN. Research Area Cell biology Neurobiology Stem cells Cell type markers Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Nucleostemin: 101-160/548 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Nucleostemin is a protein found in the nucleoli of embryonic stem cells, adult CNS stem cells, primitive cells in the bone marrow and cancer cells. It is not in the differentiated cells of most adult tissues. It has been suggested to play a role in controlling the cell cycle progression in stem cells and cancer cells.
Function:
May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.
Subunit:
Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity).
Subcellular Location:
Nucleus. Nucleus. nucleolus. Shuttles between the nucleus and nucleolus.
Tissue Specificity:
Increased levels in lung tissue in cancer patients.
Similarity:
Belongs to the MMR1/HSR1 GTP-binding protein family.
Contains 1 G (guanine nucleotide-binding) domain.
SWISS:
Q9BVP2
Gene ID:
26354
Database links:Entrez Gene: 26354 Human
Entrez Gene: 30877 Mouse
Omim: 608011 Human
SwissProt: Q9BVP2 Human
SwissProt: Q8CI11 Mouse
Unigene: 313544 Human
Unigene: 88512 Mouse
Unigene: 4110 Rat
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