Product Name	IEX1
Chinese Name	分化相关基因2蛋白/立即早期反应蛋白抗体
Alias	IEX1; PRG1; Anti death protein; Differentiation dependent gene 2 protein; DIF 2; DIF2; Differentiation dependent gene 2; Differentiation dependent gene 2 protein; Differentiation-dependent gene 2 protein; Expressed in pancreatic carcinoma; GLY 96; GLY96; Gly96 mouse homolog of; IER 3; IER3; IEX 1; IEX 1L; IEX1_HUMAN; IEX1L; Immediate early protein GLY96; Immediate early response 3; Immediate early response 3 protein; Immediately early gene X 1; PACAP responsive gene 1; PACAP responsive gene 1 protein; PACAP-responsive gene 1 protein; PRG 1; Protein DIF 2; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1.
Research Area	Tumour  Cell biology  Developmental biology  Signal transduction  Stem cells  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IEX1/Differentiation dependent gene 2 protein: 85-156/156 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]. Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. Subunit: Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation. Subcellular Location: Membrane; Single-pass type II membrane protein. Post-translational modifications: Glycosylated. Similarity: Belongs to the IER3 family. SWISS: P46695 Gene ID: 8870 Database links: Entrez Gene: 8870 Human Entrez Gene: 15937 Mouse Omim: 602996 Human SwissProt: P46695 Human SwissProt: P46694 Mouse Unigene: 730861 Human Unigene: 76095 Human Unigene: 25613 Mouse

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