Product Name	Calpain 12
Chinese Name	钙激活蛋白酶12抗体
Alias	Calpain12; Calpain-12; CAPN 12; CAPN12; EC 3.4.22.; MGC20576; CAN12_HUMAN.
literatures	Specific References  (1)     |     SL6798R has been referenced in 1 publications. [IF=3.309] Jae Woong Kim. et al. Concurrent inactivating mutations and expression losses of RGS2, HNF1A, and CAPN12 candidate tumor suppressor genes in colon cancers. PATHOL RES PRACT. 2023 Jan;241:154288  IHC ;  Human.   PubMed:36566600
Research Area	Cell biology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Calpain 12: 201-310/719
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Calpains are a family of cytosolic calcium activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin and cytoskeletal interactions, and synaptic plasticity. Calpain 12 was first described in the mouse, most strongly in the skin, and maps to mouse chromosome 7. Isoforms differ in the carboxyterminal ends, ending with aberrant domain III and lacking domain IV. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV, making Calpain 12 most similar to calpains 1 and 2. Function: Calcium-regulated non-lysosomal thiol-protease (By similarity). Similarity: Belongs to the peptidase C2 family. Contains 1 calpain catalytic domain. Contains 1 EF-hand domain. SWISS: Q6ZSI9 Gene ID: 147968 Database links: Entrez Gene: 147968 Human Entrez Gene: 60594 Mouse Entrez Gene: 308476 Rat Omim: 608839 Human SwissProt: Q6ZSI9 Human SwissProt: Q9ER56 Mouse Unigene: 731775 Human Unigene: 476990 Mouse Unigene: 219171 Rat

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