Product Name	Apaf1 Interacting Protein
Chinese Name	凋亡蛋白活性因子1相互作用蛋白抗体
Alias	MTNB_HUMAN; Apaf1 Interacting Protein; APIP2; CG129; CGI 29; MMRP19; MTRu 1 P dehydratase; Probable methylthioribulose 1 phosphate dehydratase.
Research Area	Cell biology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human APIP: 151-242/242
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c-dependent and APAF1-mediated cell death. Subunit: Interacts with APAF1. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed with high expression in skeletal muscle, heart and kidney. Similarity: Belongs to the aldolase class II family. MtnB subfamily. SWISS: Q96GX9 Gene ID: 51074 Database links: Entrez Gene: 508345 Cow Entrez Gene: 475943 Dog Entrez Gene: 32334 Fruit fly (Drosophila melanogaster) Entrez Gene: 100732536 Guinea pig Entrez Gene: 51074 Human Entrez Gene: 56369 Mouse Entrez Gene: 100525733 Pig Entrez Gene: 295961 Rat Entrez Gene: 447941 Zebrafish Omim: 612491 Human SwissProt: Q0VCJ2 Cow SwissProt: Q9VY93 Fruit fly (Drosophila melanogaster) SwissProt: Q96GX9 Human SwissProt: Q8BP46 Mouse SwissProt: Q9WVQ5 Mouse SwissProt: Q66I75 Zebrafish Unigene: 5343 Fruit fly (Drosophila melanogaster) Unigene: 447794 Human Unigene: 24772 Mouse Unigene: 15452 Rat

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