Product Name	Aquaporin 8
Chinese Name	水Channel protein8抗体
Alias	AQP 8; AQP-8; AQP8; AQP8_HUMAN; Aquaporin 8; Aquaporin-8; Aquaporin8.
literatures	Specific References  (7)     |     SL6786R has been referenced in 7 publications. [IF=7.675] Yimeng Fan. et al. Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation. ANTIOXIDANTS-BASEL. 2023 May;12(5):1122  IHC ;  Rat.   PubMed:37237988 [IF=6.107] Xiao-Hu Zhao. et al. Integrative analysis reveals marker genes for intestinal mucosa barrier repairing in clinical patients. ISCIENCE. 2023 May;:106831  WB ;  Human.   PubMed:37250791 [IF=5.279] Qi-Le Zuo. et al. Influences of Xylitol Consumption at Different Dosages on Intestinal Tissues and Gut Microbiota in Rats. J Agr Food Chem. 2021;XXXX(XXX):XXX-XXX  IHC ;  rat.   PubMed:34590865 [IF=5.165] Chenhong Lin. et al. Osmotic pressure induces translocation of aquaporin-8 by P38 and JNK MAPK signaling pathways in patients with functional constipation. DIGEST LIVER DIS. 2023 Feb;:  WB,IF ;  Human.   PubMed:36792433 [IF=3.414] Li X et al. Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. In loperamide-induced rats. J Ethnopharmacol. 2019 Aug 10;240:111961.  WB ;  Rat.   PubMed:31102614 [IF=2.299] Ferré-Dolcet L et al. Uterine and placental specific localization of AQP2 and AQP8 is related with changes of serum progesterone levels in pregnant queens. Theriogenology. 2019 Oct 1;142:149-157.  WB&IHF ;  queen.   PubMed:31593882 [IF=1.09] Wang, Wei, et al. "Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance." World journal of surgical oncology 10.1 (2012): 1-5.  IHC-P ;  Human.   PubMed:23148732
Research Area	Cell biology  Signal transduction  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Aquaporin 8: 101-220/261 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Forms a water-specific channel; mercury-sensitive. plays a role in water transport across hepatocyte membranes [RGD, Feb 2006] Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed only in pancreas and colon. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. SWISS: O94778 Gene ID: 343 Database links: Entrez Gene: 343 Human Omim: 603750 Human SwissProt: O94778 Human Unigene: 176658 Human
Product Picture	Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-AQP8/Aquaporin 8 Polyclonal Antibody, Unconjugated(SL6786R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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