Product Name	SERBP1
Chinese Name	纤溶酶原激活物抑制剂1 RNABinding protein抗体
Alias	CGI 55; CHD3IP; Chromodomain helicase DNA binding protein 3 interacting protein; HABP4L; PAI 1 mRNA binding protein; PAI RBP1; PAIRBP1; Plasminogen activator inhibitor 1 RNA binding protein; SERPINE1 mRNA binding protein 1; PAIRB_HUMAN.
Research Area	Tumour  Cell biology  immunology  Signal transduction  TumourCell biologyMaker  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SERBP1: 301-408/408
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SERBP1 (Plasminogen activator inhibitor 1 RNA-binding protein) may play a role in the regulation of mRNA stability. SERBP1 binds to the 3’-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. SERBP1 interacts with CHD3 and is localized in cytoplasmic and nuclear. It is expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. Function: May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Subunit: Interacts with CHD3 and TDRD3. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Tissue Specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. SWISS: Q8NC51 Gene ID: 26135 Database links: Entrez Gene: 26135 Human Entrez Gene: 66870 Mouse Entrez Gene: 246303 Rat Omim: 607378 Human SwissProt: Q8NC51 Human SwissProt: Q9CY58 Mouse SwissProt: Q6AXS5 Rat Unigene: 530412 Human Unigene: 240490 Mouse Unigene: 440861 Mouse Unigene: 203108 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SERBP1) Polyclonal Antibody, Unconjugated (SL6734R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SERBP1) Polyclonal Antibody, Unconjugated (SL6734R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SERBP1) Polyclonal Antibody, Unconjugated (SL6734R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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