Product Name	Upstream Binding Protein 1
Chinese Name	上游Binding protein1抗体
Alias	LBP 1a; Cp2b; DKFZp686L1745; LBP 1a; LBP 1B; LBP1; LBP1A; LBP1B; NF2d9; Upstream binding protein 1; Transcription factor LBP-1; UBIP1_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  transcriptional regulatory factor  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Upstream Binding Protein 1: 351-450/540
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Function: UBP1 is an important SF1 independent transcriptional activator stimulating P450scc expression in human placental JEG 3 cells. Subunit: Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Subcellular Location: Nucleus. Tissue Specificity: Expressed in adrenal tissue, JEG-3, NCI-H295A, HepG2 and HeLa cell lines. Similarity: Belongs to the grh/CP2 family. CP2 subfamily. SWISS: Q9NZI7 Gene ID: 7342 Database links: Entrez Gene: 7342 Human Entrez Gene: 22221 Mouse Entrez Gene: 301038 Rat Omim: 609784 Human SwissProt: Q86Y57 Human SwissProt: Q9NZI7 Human SwissProt: Q60786 Mouse SwissProt: Q811S7 Mouse SwissProt: Q8BH21 Mouse Unigene: 118041 Human Unigene: 729120 Human Unigene: 28052 Mouse Unigene: 386808 Mouse Unigene: 15705 Rat
Product Picture	Sample: Pancreas (Mouse) Lysate at 40 ug Primary: Anti- Upstream Binding Protein 1 (SL6730R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 56 kD

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