Product Name	GPR24
Chinese Name	G protein-coupled receptor24抗体
Alias	MCHR; G protein coupled receptor 24; GPCR MCH1; GPCR SLC/MCH1; GPR24; MCH receptor 1; MCH1R; Melanin concentrating hormone receptor 1; SLC-1; Somatostatin receptor like protein; MCHR1_HUMAN.
Research Area	Cell biology  Neurobiology  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	46kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MCHR/GPR24: 75-180/422 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MCHR, a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. MCHR can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, MCHR does not seem to bind somatostatin. Function: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Subunit: Interacts with NCDN. Subcellular Location: Cell Membrane; multi-pass membrane protein Tissue Specificity: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q99705 Gene ID: 2847 Database links: Entrez Gene: 2847 Human Entrez Gene: 207911 Mouse Entrez Gene: 83567 Rat Omim: 601751 Human SwissProt: Q99705 Human SwissProt: Q8JZL2 Mouse SwissProt: P97639 Rat Unigene: 248122 Human Unigene: 323523 Mouse Unigene: 10822 Rat
Product Picture	Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GPR24 Polyclonal Antibody, Unconjugated(SL6626R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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