Product Name	GAT1/GABA Transporter 1
Chinese Name	γ氨基丁酸运载蛋白1抗体
Alias	GABATHG; GABATR; GABT 1; GABT1; GAT-1; SLC6A1; Sodium and chloride dependent GABA transporter 1; Solute carrier family 6 (neurotransmitter transporter GABA) member 1; Solute carrier family 6 member 1.
literatures	Specific References  (1)     |     SL6617R has been referenced in 1 publications. [IF=3.15] Chen C et al. Overexpression of SLC6A1 associates with drug resistance and poor prognosis in prostate cancer. BMC Cancer . 2020 Apr 6;20(1):289.  WB ;  human.   PubMed:32252682
Research Area	Cell biology  Neurobiology  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Dog, Pig, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	66kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GABA Transporter 1: 151-250/599 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GABA Transporter 1/GAT1 is a gamma-amino butyric acid (GABA) transporter. After its release from interneurons in the CNS, the major inhibitory neurotransmitter GABA is taken up by GABA transporters (GATs). The predominant neuronal GABA transporter GAT1 is localized in GABAergic axons and nerve terminals, where it is thought to influence GABAergic synaptic transmission by removing GABA from the synaptic cleft. Function: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Subunit: Interacts with MPP5. Subcellular Location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons. Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. SWISS: P30531 Gene ID: 6529 Database links: Entrez Gene: 415960 Chicken Entrez Gene: 6529 Human Entrez Gene: 232333 Mouse Entrez Gene: 79212 Rat Omim: 137165 Human SwissProt: P30531 Human SwissProt: P31648 Mouse SwissProt: P23978 Rat Unigene: 443874 Human Unigene: 5260 Mouse Unigene: 10035 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GAT1 GABA Transporter 1) Polyclonal Antibody, Unconjugated (SL6617R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GAT1) Polyclonal Antibody, Unconjugated (SL6617R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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