Product Name	ORP4/OSBP2
Chinese Name	氧化固醇Binding protein4抗体
Alias	ORP 4; ORP4; OSBLP4; OSBP-related protein 4; OSBP2; OSBPL1; OSBPL4; Oxysterol Binding Protein 2; Oxysterol Binding Protein-like 1; oxysterol binding protein-related protein 4; OSBP2_HUMAN.
Research Area	Tumour  Cardiovascular  Cell biology  Signal transduction  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	101kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ORP4/OSBP2: 221-320/916
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells. Function: Binds 7-ketocholesterol. Subcellular Location: Membrane; Peripheral membrane protein Tissue Specificity: Expressed mainly in retina, testis, and fetal liver. Similarity: Belongs to the OSBP family. Contains 1 PH domain. SWISS: Q969R2 Gene ID: 23762 Database links: Entrez Gene: 23762 Human Entrez Gene: 74309 Mouse Entrez Gene: 305475 Rat Omim: 606729 Human SwissProt: Q969R2 Human Unigene: 7740 Human Unigene: 61022 Mouse
Product Picture	Sample: K562 (Human) Cell Lysate at 30 ug Primary: Anti- ORP4’OSBP2 (SL-6560R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 101 kD Observed band size: 120 kD

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