Product Name	Rab25
Chinese Name	癌基因RAS相关蛋白Rab25抗体
Alias	CATX 8; CATX-8; CATX8; member RAS oncogene family; RAB25; RAB-25; RAB25_HUMAN; Ras related protein Rab 25; Ras-related protein Rab-25.
Research Area	Tumour  Signal transduction  transcriptional regulatory factor  TumourCell biologyMaker  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Rab25: 145-190/213
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface Function: Involved in the regulation of cell survival. Promotesinvasive migration of cells in which it functions to localize andmaintain integrin alpha-V/beta-1 at the tips of extendingpseudopodia. Increases the rates of ovarian and breast cancersprogression and aggressiveness by modulating cellular processessuch as proliferation, survival and migration of epithelial tumorcells. May selectively regulate the apical recycling pathway.Together with MYO5B regulates transcytosis Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 andRAB11FIP4. Interacts (via the hypervariable C-terminal region) withITGB1 (via the cytoplasmic region); the interaction isGTP-dependent. Interacts with ITGAV. Associates with the integrinalpha-V/beta-1 heterodimer. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmicside (Potential). Cell projection, pseudopodium membrane.Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1in vesicles at the pseudopodial tips. Tissue Specificity: Expressed in ovarian epithelium (NOE) andbreast tissue. Expressed in ovarian cancer; expression is increasedrelative to NOE cells. Expression in ovarian cancer is stagedependent, with stage III and stage IV showing higher levels thanearly stage cancers. Expressed in breast cancer; expression isincreased relative to normal breast tissue. Similarity: Belongs to the small GTPase superfamily. Rab family. SWISS: P57735 Gene ID: 57111 Database links: Entrez Gene: 57111 Human Entrez Gene: 53868 Mouse Omim: 612942 Human SwissProt: P57735 Human SwissProt: Q9WTL2 Mouse SwissProt: P46629 Rabbit Unigene: 632469 Human Unigene: 26994 Mouse

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