Product Name	PMCA2
Chinese Name	The cell membrane钙转运ATP酶抗体
Alias	ATP2B1; ATP2B2; ATP2B3; ATP2B4; ATPase Ca++ transporting plasma membrane 1; ATPase Ca++ transporting plasma membrane 2; ATPase Ca++ transporting plasma membrane 3; ATPase Ca++ transporting plasma membrane 4; Plasma membrane calcium transporting ATPase 1; Plasma membrane calcium transporting ATPase 2; Plasma membrane calcium transporting ATPase 3; Plasma membrane calcium transporting ATPase 4; PMCA1; PMCA2; PMCA3; PMCA4; AT2B2_HUMAN.
literatures	Specific References  (1)     |     SL6499R has been referenced in 1 publications. [IF=14.318] Schmidt et al. Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance. (2017) Neuron. 96:827-838.e9  WB ;  Rat&Mouse.   PubMed:29056295
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	137kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PMCA: 361-460/1243 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. SWISS: Q01814 Gene ID: 491 Database links: Entrez Gene: 491 Human Entrez Gene: 11941 Mouse Entrez Gene: 24215 Rat Omim: 108733 Human SwissProt: Q01814 Human SwissProt: Q9R0K7 Mouse SwissProt: P11506 Rat Unigene: 268942 Human Unigene: 321755 Mouse Unigene: 90982 Rat
Product Picture	Blank control: H9C2 (blue) Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:100 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 3μl in 100 μL1X PBS containing 0.5% BSA(green).

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