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Product Name ITPR3 Chinese Name 5-三磷酸肌醇受体3抗体 Alias IP3R-III; IP3 receptor isoform 3; 4 antibody 5-trisphosphate receptor; 5-trisphosphate receptor type 3; FLJ36205; Inositol 1; Inositol 1,4,5 trisphosphate receptor type 3; IP3 receptor; IP3R 3; IP3R; IP3R3; ITPR 3; ITPR3; ITPR3_HUMAN; Type 3 inositol 1; Type 3 inositol 1,4,5 trisphosphate receptor; Type 3 InsP3 receptor. literatures Specific References (2) | SL6471R has been referenced in 2 publications.[IF=4.155] Junjun Peng. et al. Endoplasmic reticulum-mitochondria coupling attenuates vanadium-induced apoptosis via IP3R in duck renal tubular epithelial cells. J INORG BIOCHEM. J Inorg Biochem. 2022 Apr;:111809 WB ; Duck.[IF=2.6] Luan, Xinhong, et al. "Comparative proteomic analysis of pituitary glands from Huoyan geese between pre-laying and laying periods using an iTRAQ-based approach." PLOS ONE 12.9 (2017): e0185253. WB ; Other Species.Research Area Tumour Cell biology Neurobiology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Dog, (predicted: Human, Rat, Chicken, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 294kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ITPR3: 21-120/2671 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.
Function:
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.
Subunit:
Homotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with CABP1. Interacts with TMBIM4/LFG4.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Expressed in intestinal crypt and villus epithelial cells.
Similarity:
Belongs to the InsP3 receptor family.
Contains 5 MIR domains.
SWISS:
Q14573
Gene ID:
3710
Database links:
- Entrez Gene: 3710 Human
- Omim: 147267 Human
- SwissProt: Q14573 Human
- Unigene: 65758 Human
Product Picture Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ITPR3) Polyclonal Antibody, Unconjugated (SL6471R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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