Product Name	CHRNA3
Chinese Name	烟碱型乙酰胆碱受体α3抗体
Alias	Nicotinic Acetylcholine Receptor alpha 3; ACHA3_HUMAN; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypeptide 3; CHRNA 3; CHRNA3; CHRNA-3; NACHRA 3; NACHRA3; Neuronal acetylcholine receptor protein alpha 3 chain precursor; Neuronal acetylcholine receptor subunit alpha 3; Neuronal acetylcholine receptor subunit alpha-3; Neuronal nicotinic acetylcholine receptor alpha 3 subunit.
Research Area	Cell biology  Neurobiology  Signal transduction  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CHRNA3/AChRα3: 101-200/505
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChR?, also known as LNCR2, PAOD2, NACHRA3 or CHRNA3, is a 505 amino acid multi-pass membrane protein that belongs to the ligand-gated ion channel receptor family and may play a role in neurotransmission. Function: After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. Subunit: Neuronal AChR is composed of two different types ofsubunits: alpha and beta. Alpha-3 subunit can be combined to beta-2or beta-4 to give rise to functional receptors. Interacts withRIC3; which is required for proper folding and assembly. Subcellular Location: Cell junction, synapse, postsynaptic cellmembrane; Multi-pass membrane protein. Cell membrane; Multi-passmembrane protein. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9)family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Alpha-3/CHRNA3 sub-subfamily. SWISS: P32297 Gene ID: 1136 Database links: Entrez Gene: 1136 Human Entrez Gene: 110834 Mouse Entrez Gene: 25101 Rat Omim: 118503 Human SwissProt: P32297 Human SwissProt: Q8R4G9 Mouse SwissProt: P04757 Rat Unigene: 89605 Human Unigene: 63569 Mouse Unigene: 10996 Rat

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