Product Name	CDH11/OB Cadherin
Chinese Name	钙粘附蛋白-11抗体
Alias	Cadherin-11; OB-Cadherin; CDH11, CAD11; CAD11_HUMAN; Cadherin 11; Cadherin 11 type 2; Cadherin 11 type 2 OB cadherin (osteoblast); Cadherin-11; Cdh11; CDHOB; OB; OB-cadherin; OBcadherin; OSF-4; OSF4; Osteoblast cadherin.
literatures	Specific References  (1)     |     SL6444R has been referenced in 1 publications. [IF=2.311] Wang Q et al. Clinical and prognostic association of oncogene cadherin 11 in gastric cancer. Oncol Lett . 2020 Jun;19(6):4011-4023.  IHC ;  human.   PubMed:32391104
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	90kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CDH11/OB-Cadherin: 301-300/796 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The cadherins are a family of Ca++-dependent adhesion molecules that influence cell-cell binding and are critical to the maintenance of tissue structure and morphogenesis. OB-cadherin (osteoblast-cadherin, cadherin-11, OSF-4) has two forms, OB-cadherin-1 and OB-cadherin-2. OB-cadherin-2 has a truncated cytoplasmic domain, missing amino acids 694-796. Both OB-cadherins are expressed in osteoblastic cell lines with low expression seen in lungs, testis and brain. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Subunit: Interacts with PCDH8 (By similarity). Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. DISEASE: Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Similarity: Contains 5 cadherin domains. SWISS: P55287 Gene ID: 1009 Database links: Entrez Gene: 1009 Human Entrez Gene: 12552 Mouse Entrez Gene: 84407 Rat Omim: 600023 Human SwissProt: P55287 Human SwissProt: P55288 Mouse Unigene: 116471 Human Unigene: 1571 Mouse Unigene: 8900 Rat
Product Picture	Sample: Lane 1: Mouse Ovary tissue lysates Lane 2: Human MDA-MB-231 cell lysates Primary: Anti-CDH11/OB Cadherin (SL6444R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 90 kDa Observed band size: 120 kDa

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