Product Name	P15RS
Chinese Name	细胞周期依赖性激酶抑制相关蛋白抗体
Alias	Cyclin dependent kinase 2B inhibitor related protein; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein); Cyclin dependent kinase inhibitor 2B related protein; Cyclin dependent kinase inhibitor related protein; Hypothetical protein FLJ10656; p15INK4B related protein; Putative uncharacterized protein P15RS; Regulation of nuclear pre mRNA domain containing 1A; RPRD1A; RPR1A_HUMAN.
Research Area	Cell biology  Cyclin  Kinases and Phosphatases  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RPRD1A/P15RS: 231-312/312
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	P15RS is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) (CDKN2B; MIM 600431) and may have a role in cell cycle regulation Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. Subunit: Associates with the RNA polymerase II complex. Similarity: Belongs to the UPF0400 (RTT103) family. Contains 1 CID domain. SWISS: Q96P16 Gene ID: 55197 Database links: Entrez Gene: 420953 Chicken Entrez Gene: 504355 Cow Entrez Gene: 55197 Human Entrez Gene: 225283 Mouse Omim: 610347 Human SwissProt: Q5ZM30 Chicken SwissProt: Q0P5J9 Cow SwissProt: Q96P16 Human SwissProt: Q8VDS4 Mouse Unigene: 464912 Human Unigene: 28427 Mouse

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