Product Name	ORP8
Chinese Name	氧化固醇Binding protein8抗体
Alias	MST120; MSTP120; ORP 8; OSBP related protein 8; OSBP10; OSBPL8; Oxysterol binding protein like 8; Oxysterol binding protein like protein 8; Oxysterol binding protein related protein 8; OSBL8_HUMAN.
Research Area	Cardiovascular  Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	101kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ORP8: 121-220/889
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ORP8 is a member of the oxysterol-binding protein related protein family. In humans, the gene family consists of 12 members, and extensive splice variation increases the number of encoded protein products substantially. The ORPs have been implicated as sterol sensors that regulate a number of cellular functions including sterol and neutral lipid metabolism, intracellular lipid transport, membrane trafficking and cell signaling. ORP8 has been recently shown to act as a sterol sensor that affects the reverse cholesterol transport process via modulation of ABCA1 expression and macrophage cholesterol efflux. Subcellular Location: Endoplasmic reticulum Tissue Specificity: Widely expressed. Similarity: Belongs to the OSBP family. Contains 1 PH domain. SWISS: Q9BZF1 Gene ID: 114882 Database links: Entrez Gene: 114882 Human Entrez Gene: 237542 Mouse Omim: 606736 Human SwissProt: Q9BZF1 Human SwissProt: B9EJ86 Mouse Unigene: 220204 Mouse

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