Product Name	ApoB
Chinese Name	载LipoproteinB抗体
Alias	Apo B 100; Apo B; Apo B-100; Apo B-48; ApoB 100; ApoB 48; ApoB; APOB protein; APOB_HUMAN; Apolipoprotein B 100; Apolipoprotein B 48; Apolipoprotein B; Apolipoprotein B-48; FLDB.
literatures	Specific References  (1)     |     SL6333R has been referenced in 1 publications. [IF=11.47] Choi, Won Hoon, et al. "Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation." Nature Communications 7 (2016).  WB ;  Human.   PubMed:26957043
Research Area	Tumour  Cardiovascular  Cell biology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	241/513kDa
Cellular localization	cytoplasmic Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Apolipoprotein B: 1501-1700/4563
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Subcellular Location: Secreted. Post-translational modifications: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. DISEASE: Defects in APOB are a cause of familialhypobetalipoproteinemia type 1 (FHBL1) [MIM:107730]. A disordercharacterized by highly reduced plasma concentrations of lowdensity lipoproteins, and dietary fat malabsorption. Clinicalpresentation may vary from no symptoms to severe gastrointestinaland neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defectiveapolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantlyinherited disorder of lipoprotein metabolism leading tohypercholesterolemia and increased proneness to coronary arterydisease (CAD). The plasma cholesterol levels are dramaticallyelevated due to impaired clearance of LDL particles by defectiveAPOB/E receptors. Note=Defects in APOB associated with defects in othergenes (polygenic) can contribute to hypocholesterolemia. Similarity: Contains 1 vitellogenin domain. SWISS: P04114 Gene ID: 338 Database links: Entrez Gene: 338 Human Entrez Gene: 238055 Mouse Omim: 107730 Human SwissProt: P04114 Human SwissProt: E9Q414 Mouse Unigene: 120759 Human Unigene: 221239 Mouse

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