Product Name	ABCA2
Chinese Name	三磷酸腺苷结合盒Transporter2抗体
Alias	ABC2; ATP binding cassette 2; ATP binding cassette sub family A member 2; ATP binding cassette transporter 2; ATP binding cassette, sub family A (ABC1), member 2; ATP binding cassette, sub family A, member 2; ATP binding cassette, sub family B (MDR/TAP), member 2;ABCA2_HUMAN.
Research Area	Cardiovascular  Cell biology  immunology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	270kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ABCA2: 1901-2100/2435
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene (from EntrezGene). Function: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Subcellular Location: Endosome. Membrane. Lysosome. Membrane. Forms discrete, punctate intracellular vesicles. Tissue Specificity: Highy expressed in the brain, whereas lower levels of expression is observed in kidney and liver. Similarity: Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. SWISS: Q9BZC7 Gene ID: 20 Database links: Entrez Gene: 480669 Dog Entrez Gene: 101132590 Gorilla Entrez Gene: 100067889 Horse Entrez Gene: 20 Human Entrez Gene: 11305 Mouse Entrez Gene: 79248 Rat Omim: 600047 Human SwissProt: Q9BZC7 Human SwissProt: P41234 Mouse SwissProt: Q9ESR9 Rat Unigene: 421202 Human Unigene: 2210 Mouse Unigene: 13115 Rat

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