Product Name	CTBP2
Chinese Name	C末端Binding protein2抗体
Alias	C terminal binding protein 2; C-terminal-binding protein 2; CtBP2; CTBP2_HUMAN; ribeye.
Research Area	Cell biology  Neurobiology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CTBP2: 54-140/445
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses. Subunit: Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression. Interacts with PNN, NRIP1 and WIZ. Subcellular Location: Nucleus. Cell junction, synapse. Tissue Specificity: Ubiquitous. Highest levels in heart, skeletalv muscle, and pancreas. Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. SWISS: P56545 Gene ID: 1488 Database links: Entrez Gene: 281730 Cow Entrez Gene: 1488 Human Entrez Gene: 13017 Mouse Entrez Gene: 81717 Rat Omim: 602619 Human SwissProt: Q0VCQ1 Cow SwissProt: P56545 Human SwissProt: P56546 Mouse SwissProt: Q9EQH5 Rat Unigene: 501345 Human Unigene: 246240 Mouse Unigene: 389984 Mouse Unigene: 138124 Rat

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