Product Name	NANOS2
Chinese Name	生殖细胞增殖相关蛋白NANOS2抗体
Alias	NANO2_HUMAN; Nanos homolog 2; Nanos homolog 2 Drosophila; NANOS2; NOS-2; NOS2.
literatures	Specific References  (1)     |     SL6314R has been referenced in 1 publications. [IF=8.079] Honda Naoto. et al. Roles of microglia/macrophage and antibody in cell sheet transplantation in the central nervous system. STEM CELL RES THER. 2022 Dec;13(1):1-11  IHC ;  Mouse.   PubMed:36089602
Research Area	Cell biology  immunology  Developmental biology  Signal transduction  Stem cells  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NANOS2: 45-138/138
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Required to support proliferation and self-renewal of proximal germ cells in males only. Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. Essential for spermatogonia formation. Function: Plays a key role in the sexual differentiation of germcells by promoting the male fate but suppressing the female fate.Represses the female fate pathways by suppressing meiosis, which inturn results in the promotion of the male fate. Maintains thesuppression of meiosis by preventing STRA8 expression, which isrequired for premeiotic DNA replication, after CYP26B1 isdecreased. Regulates the localization of the CCR4-NOT deadenylationcomplex to P-bodies and plays a role in recruiting the complex totrigger the degradation of mRNAs involved in meiosis. Required forthe maintenance of the spermatogonial stem cell population. Notessential for the assembly of P-bodies but is required for themaintenance of their normal state (By similarity). Subunit: Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 (Bysimilarity). Subcellular Location: Cytoplasm. Cytoplasm, P-body (Bysimilarity). Cytoplasm, perinuclear region. Note=Localizes atP-bodies during gonocyte development (By similarity). More abundantin perinuclear region of the cytoplasm of the germ cells of theadult testis. Tissue Specificity: Testis and ovary. Expression found in severalspermatogenic stages: in cells on the periphery of the tubuleswhich could correspond to spermatogonia, in spermatocytes and inround spermatids (at protein level). Similarity: Belongs to the nanos family. Contains 1 nanos-type zinc finger. SWISS: P60321 Gene ID: 339345 Database links: UniProtKB/Swiss-Prot: P60321.1

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