Product Name	4 Hydroxynonenal
Chinese Name	4-羟基壬烯醛抗体
Alias	4-Hydroxy-2-Nonenal; 4Hydroxynonenal; 4-Hydroxynonenal; HNE; 4HNE; 4-HNE; (E)-4-Hydroxy-2-nonenal; 2-Nonenal, 4-hydroxy-, (2E)-; (2E)-4-Hydroxy-2-nonenal; 4-Hydroxy-2(E)-nonenal;   (E)-4-羟基-2-壬烯醛; 4-羟基壬醛;
literatures	Specific References  (61)     |     SL6313R has been referenced in 61 publications. [IF=31.743] Hannah N. Bell. et al. Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance. Cancer Cell. 2021 Dec;:  IF ;  Mouse.   PubMed:34951957 [IF=16.019] Spinetti G et al. microRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia. Diabetes Care 2020 07;437(7)  IF ;  Human.   PubMed:32358022 [IF=14.957] Fantian Zeng. et al. Ferroptosis MRI for early detection of anticancer drug–induced acute cardiac/kidney injuries. SCI ADV. 2023 Mar;9(10)  IHC ;  Mouse.   PubMed:36888714 [IF=12.81] Haberman, Yael, et al. "Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature." The Journal of Clinical Investigation 124.124 (8) (2014): 0-0.  IHC-P ;  Human.   PubMed:25003194 [IF=11.864] Rashi Singhal. et al. HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. J Clin Invest. 2021 Apr;:  IHC ;  Mouse.   PubMed:33914705 [IF=10.787] Taisei Nagasaki. et al. A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease. REDOX BIOL. 2022 Aug;54:102371  IHC ;  Human.   PubMed:35763935 [IF=10.787] Dong-Hyun Kim. et al. Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes. REDOX BIOL. 2022 Aug;54:102382  IHC ;  Mouse.   PubMed:35767918 [IF=10.787] Kuo Shen. et al. miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury. REDOX BIOL. 2023 Jun;62:102655  IF ;  Mouse.   PubMed:36913799 [IF=10.787] Sufang Zhong. et al. Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis. REDOX BIOL. 2023 Jul;63:102760  IHC ;  Rat.   PubMed:37267686 [IF=9.986] Shotaro Hayashi. et al. Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice. Redox Biol. 2020 Oct;37:101726  IHC ;  Mouse.   PubMed:32961443 [IF=9.776] Hitoshi Maeda. et al. Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH. J Control Release. 2021 Nov;:  IHC ;  Mouse.   PubMed:34856227 [IF=9.685] Yang, Youjing. et al. STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway. CELL DEATH DIS. 2022 Jun;13(6):1-14  IHC ;  Mouse.   PubMed:35668064 [IF=9.685] Park, Jung Sun. et al. 3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) induces cell death through ferroptosis and acts as a trigger of apoptosis in kidney cells. CELL DEATH DIS. 2023 Feb;14(2):1-11  IHC ;  Mouse.   PubMed:36732325 [IF=8.101] Fangfang Huang. et al. STAT3-mediated ferroptosis is involved in ulcerative colitis. FREE RADICAL BIO MED. 2022 Aug;188:375  IHC ;  Mouse.   PubMed:35779691 [IF=8.101] QianYu Lu. et al. Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway. FREE RADICAL BIO MED. 2023 Feb;195:89  IF ;  Human, Mouse.   PubMed:36581059 [IF=7.892] Yung-Fong Tsai. et al. Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress. BIOMED J. 2022 Sep;:  IHC ;  Mouse.   PubMed:36103985 [IF=7.865] Sandro Sponga. et al. Preservation by cold storage vs ex vivo normothermic perfusion of marginal donor hearts: clinical, histopathologic, and ultrastructural features. J Heart Lung Transpl. 2020 Dec;39:1408  IF,IHC ;  Human.   PubMed:33041182 [IF=7.675] Lianxiang Luo. et al. Identification of Lipocalin 2 as a Ferroptosis-Related Key Gene Associated with Hypoxic-Ischemic Brain Damage via STAT3/NF-κB Signaling Pathway. ANTIOXIDANTS-BASEL. 2023 Jan;12(1):186  WB ;  Mouse.   PubMed:36671050 [IF=7.675] Bo-Jeong Pyun. et al. Caesalpinia sappan Linn. Ameliorates Allergic Nasal Inflammation by Upregulating the Keap1/Nrf2/HO-1 Pathway in an Allergic Rhinitis Mouse Model and Nasal Epithelial Cells. ANTIOXIDANTS-BASEL. 2022 Nov;11(11):2256  IHC ;  Mouse.   PubMed:36421442 [IF=7.666] Ricarda Haustein. et al. C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation. CELLS-BASEL. 2023 Jan;12(3):443  IF ;  Mouse.   PubMed:36766785 [IF=7.666] Huan Yang. et al. Elabela: Negative Regulation of Ferroptosis in Trophoblasts via the Ferritinophagy Pathway Implicated in the Pathogenesis of Preeclampsia. CELLS-BASEL. 2023 Jan;12(1):99  IHC ;  Mouse.   PubMed:36611895 [IF=7.419] Di Zhang. et al. Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats. BIOMED PHARMACOTHER. 2022 Sep;153:113461  WB ;  Rat.   PubMed:10.1016/j.biopha.2022.113461 [IF=6.78] Hye Jeong Yun. et al. Novel TAK1 inhibitor handelin inhibits NF-kB and AP-1 to alleviate elastase-induced emphysema in mice. LIFE SCI. 2023 Jan;:121388  IHC ;  Mouse.   PubMed:36640900 [IF=6.78] Lianxiang Luo. et al. Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury. LIFE SCI. 2022 Oct;:121091  IHC ;  Mouse.   PubMed:36252699 [IF=6.78] Yung-Fong Tsai. et al. Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome. LIFE SCI. 2022 Dec;:121334  IHC ;  Mouse.   PubMed:36587789 [IF=6.78] Lianxiang Luo. et al. ACSF2-mediated ferroptosis is involved in ulcerative colitis. LIFE SCI. 2022 Dec;:121272  IHC, WB ;  Mouse.   PubMed:36509196 [IF=6.543] Qiu Ming. et al. Interleukin 10 Attenuates Angiotensin II-Induced Aortic Remodelling by Inhibiting Oxidative Stress-Induced Activation of the Vascular p38 and NF-κB Pathways. OXID MED CELL LONGEV. 2022;2022:8244497  IF ;  Mouse.   PubMed:35528508 [IF=6.317] Bingna Cai. et al. Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis. FOOD FUNCT. 2023 Mar;:  IHC ;  Mouse.   PubMed:36974905 [IF=6.208] Sam Cho. et al. Alpha-Lipoic Acid Attenuates Apoptosis and Ferroptosis in Cisplatin-Induced Ototoxicity via the Reduction of Intracellular Lipid Droplets. INT J MOL SCI. 2022 Jan;23(18):10981  IF, WB ;  Mouse.   PubMed:36142894 [IF=5.846] Kai Xu. et al. GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis. FRONT CARDIOVASC MED. 2022; 9: 907747  IHC ;  Mouse.   PubMed:35722096
Product Type	Small molecule anti
Research Area	Cell biology  immunology  Signal transduction  Apoptosis  Drugs and Compounds
Immunogen Species	Rabbit
Clonality	Polyclonal
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	0.156kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated 4-Hydroxynonenal
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Reactive oxygen and nitrogen species (ROS/RNS) have taken center stage in the field of signal transduction. The enzymes responsible for the production of ROS and RNS have been unraveled and the participation of these species in numerous signaling pathways has been documented. The next step is to identify the targets of ROS and RNS and the mechanisms by which they alter their activity in the affected signaling pathway. This book provides relevant chemistry that can be applied across signaling systems and summarizes the current state of knowledge in the area of redox signaling. ROS and RNS have been implicated in inflammation, aging and cancer. Subcellular Location: Cytoplasmic SWISS: N/A CAS: N/A
Product Picture	Sample: Lane 1: 4HNE-BSA (0.1 µg) Lane 2: BSA (0.1 µg) Primary: Anti-4 Hydroxynonenal (SL6313R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 0.156 kDa Observed band size: 67 kDa

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