Product Name	IL-6
Chinese Name	白介素6抗体
Alias	Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin-6; Interleukin-6; Interleukin6; IL6_MOUSE; IL6_HUMAN.
literatures	Specific References  (20)     |     SL6309R has been referenced in 20 publications. [IF=10.753] Panhong Wu. et al. Interleukin-17A knockout or self-recovery alleviated autoimmune reaction induced by fluoride in mouse testis. SCI TOTAL ENVIRON. 2023 Apr;:163616  WB ;  Mouse.   PubMed:37086998 [IF=8.101] Ming-Xin Sun. et al. Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis. FREE RADICAL BIO MED. 2023 May;:  WB ;  Mouse.   PubMed:37201634 [IF=7.419] Tianying Hong. et al. Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells. BIOMED PHARMACOTHER. 2023 Jul;163:114755  WB,IHC ;  Human,Mouse.   PubMed:37105072 [IF=7.233] Chen X et al. A photothermal-triggered nitric oxide nanogenerator combined with siRNA for precise therapy of osteoarthritis by suppressing macrophage inflammation.Nanoscale. 2019 Apr 4;11(14):6693-6709.  IHC-P&IF ;  Mouse.   PubMed:30900717 [IF=7.169] Xie, Zhan. et al. JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice. ACTA PHARMACOL SIN. 2022 Oct;:1-16  IF ;  Mouse.   PubMed:36280689 [IF=7.097] Chuping Zheng. et al. The cellular immunotherapy of integrated photothermal anti-oxidation Pd-Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis. Acta Pharm Sin B. 2021 Mar;:  IF,IHC ;  Mouse.   PubMed:10.1016/j.apsb.2021.02.021 [IF=6.656] Yuting Zhang. et al. Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells. PHYTOMEDICINE. 2023 Apr;:154809  WB ;  Human,Rat.   PubMed:37087791 [IF=6.1] Xuewen Duan. et al. IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury. BIOCHEM PHARMACOL. 2023 Jul;213:115614  IHC ;  Mouse.   PubMed:37209857 [IF=5.988] Sisi Lei. et al. Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: A network pharmacology study and in vivo experimental validation.. FRONT PHARMACOL. 2022 Sep;13:967623-967623  WB ;  Mouse.   PubMed:36172180 [IF=5.195] Liping Han. et al. Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia. J ETHNOPHARMACOL. 2023 Jun;309:116345  WB ;  Rat.   PubMed:36906155 [IF=4.996] Ren, Xiaoli. et al. Expression and significance of IL-6 and IL-8 in canine mammary gland tumors. SCI REP-UK. 2023 Jan;13(1):1-9  IHC,WB ;  Dog.   PubMed:36693957 [IF=4.411] Yudan Zhao. et al. COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis. PLOS NEGLECT TROP D. 2022 Apr;16(4):e0010402  WB ;  Mouse.   PubMed:35482821 [IF=3.943] Jia-xiang Zhang. et al. Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice. Int Immunopharmacol. 2020 Nov;88:106897  IHC ;  Mouse.   PubMed:32822909 [IF=3.77] Zhan Xie. et al. A novel model of subretinal edema induced by DL-alpha aminoadipic acid. EXP EYE RES. 2023 Jan;:109388  IF ;  Rabbit,Mouse,Rat.   PubMed:36652968 [IF=3.715] Guo Dongming. et al. IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice. BRAIN RES BULL. 2023 Jan;:  WB ;  Mouse.   PubMed:36603794 [IF=3.411] Feng Junlong. et al. Explore the Effect of Asthma Regulating HIF-1 Pathway on Sperm Quality Based on Rat Model. BIOMED RES INT. 2022;2022:4194685  WB ;  Rat.   PubMed:35620222 [IF=3.333] Min Zhou. et al. Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model of Migraine. BRAIN SCI. 2023 Apr;13(4):541  IHC ;  Rat.   PubMed:10.3390/brainsci13040541 [IF=3.046] Dan Tang. et al. Treadmill training improves respiratory function in rats after spinal cord injury by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway. NEUROSCI LETT. 2022 May;:136686  WB ;  Rat.   PubMed:35595191 [IF=2.63] Zhang Peng. et al. Study on the Mechanism of Bu-Shen-He-Mai Granules in Improving Renal Damage of Ageing Spontaneously Hypertensive Rats by Regulating Th17 Cell/Tregs Balance. EVID-BASED COMPL ALT. 2022;2022:8315503  WB ;  Rat.   PubMed:35502169 [IF=1.69] Xu et al. Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis. (2016) Mol.Med.Re. 13:4167-74  IHC ;  Rat.   PubMed:27035125
Research Area	Tumour  Cell biology  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IL-6: 171-211/211
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]. Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Subcellular Location: Secreted. Post-translational modifications: N- and O-glycosylated. DISEASE: Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Similarity: Belongs to the IL-6 superfamily. SWISS: P05231 Gene ID: 3569 Database links: Entrez Gene: 16193 Mouse Entrez Gene: 24498 Rat SwissProt: P08505 Mouse SwissProt: P20607 Rat Unigene: 1019 Mouse Unigene: 9873 Rat 白细胞介素6是一种多功能cell factor，既可由lymphocyte产生，也能由非lymphocyte合成。在体内免疫反应调节、血细胞的增生、防御机制和急性期反应中起重要作用。 白细胞介素-6是一种glycoprotein，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要作用，人的IL-6的前体有212个氨基酸。成熟形态为185个氨基酸。白细胞介素6的分子量：21KD-28KD
Product Picture	Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti-IL-6 (SL6309R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 23 kD Observed band size: 19 kD Paraformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-6) Polyclonal Antibody, Unconjugated (SL6309R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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