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Product Name KIST Chinese Name 丝氨酸/苏氨酸蛋白激酶KIST抗体 Alias kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; KIS; KIS protein kinase; KIST; Serine threonine protein kinase Kist; Serine/threonine-protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; UHMK1; UHMK1_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Cyclin transcriptional regulatory factor Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KIST/UHMK1: 331-419/419 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Function:
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Subunit:
Interacts with stathmin and CDKN1B/p27Kip1 (By similarity).
Subcellular Location:
Nucleus. Note=Mostly nuclear (By similarity).
Tissue Specificity:
Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q8TAS1
Gene ID:
127933
Database links:Entrez Gene: 127933 Human
Entrez Gene: 16589 Mouse
Omim: 608849 Human
SwissProt: Q8TAS1 Human
SwissProt: P97343 Mouse
Unigene: 127310 Human
Unigene: 209150 Mouse
Unigene: 389214 Mouse
Unigene: 89229 Rat
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