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Rabbit Anti-IMPAD1 antibody
Rabbit Anti-IMPAD1 antibody
IMP 3; IMPA3; IMPase 3; Inositol monophosphatase domain containing protein 1; Myo inositol monophosphatase A3.
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  • NO.:SL6248R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Sheep,)
    Applications:WB ELISA
    concentration:1mg/ml
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Details

Product Name IMPAD1
Chinese Name 肌醇单磷酸酶IMPA3抗体
Alias IMP 3; IMPA3; IMPase 3; Inositol monophosphatase domain containing protein 1; Myo inositol monophosphatase A3.  
Research Area Tumour  Cardiovascular  Signal transduction  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Sheep, )
Applications WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 39kDa
Cellular localization cytoplasmic The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human IMPAD1: 81-180/359 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1.

Function:
May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation

Subcellular Location:
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.

Post-translational modifications:
Contains N-linked glycan resistant to endoglycosydase H.

DISEASE:
Defects in IMPAD1 are the cause of chondrodysplasia with joint dislocations GPAPP type (CDP-GPAPP) [MIM:614078]. A condition consisting of congenital joint dislocations, chondrodysplasia with short stature, micrognathia and cleft palate, and a distinctive face.

Similarity:
Belongs to the inositol monophosphatase family.

SWISS:
Q9NX62

Gene ID:
54928

Database links:

Entrez Gene: 54928 Human

Entrez Gene: 242291 Mouse

Entrez Gene: 103689950 Rat

Entrez Gene: 312952 Rat

Omim: 614010 Human

SwissProt: Q9NX62 Human

SwissProt: Q80V26 Mouse

SwissProt: D4AD37 Rat

Unigene: 438689 Human

Unigene: 218889 Mouse

Unigene: 369779 Mouse

Unigene: 65720 Rat



Product Picture
Sample:
Muscle(Mouse) (Mouse) Lysate at 40 ug
Primary: Anti-IMPAD1 (SL6248R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 39 kD
Observed band size: 39 kD

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