Product Name	THRA1+2
Chinese Name	甲状腺激素受体α1+α2抗体
Alias	Thyroid Hormone Receptor alpha 1+2; THRA1+THRA2; AR7; Avian erythroblastic leukemia viral (v erb a) oncogene homolog; c ERBA 1; c ERBA ALPHA 2; C erbA alpha; c-erbA-1; C-erbA-alpha; cerbA protein; cerbAalpha; EAR 7; EAR 7.1; EAR 7.2; EAR-7; EAR7; ERB T 1; ERBA 1; ERBA ALPHA; ERBA; ERBA related 7; ERBA1; Erythroblastic leukemia viral (v erb a) oncogene homolog avian; NR1A 1; Nr1a1; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (verba) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7.
literatures	Specific References  (1)     |     SL6222R has been referenced in 1 publications. [IF=3.184] Gan S et al. Triiodothyronine attenuates silica-induced oxidative stress, inflammation, and apoptosis via thyroid hormone receptor α in differentiated THP-1 macrophages. Chem Res Toxicol . 2020 May 18;33(5):1256-1265.  WB ;  human.   PubMed:32223187
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Neurobiology  Signal transduction  transcriptional regulatory factor  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Zebrafish, Sheep, Cat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human THRA1 and THRA2: 101-200/490
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Function: Nuclear hormone receptor. High affinity receptor for triiodothyronine. Subunit: Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13. Subcellular Location: Nucleus. DISEASE: Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P10827 Gene ID: 7067 Database links: Entrez Gene: 7067 Human Entrez Gene: 21833 Mouse Entrez Gene: 81812 Rat Omim: 190120 Human SwissProt: P10827 Human SwissProt: P63058 Mouse SwissProt: O97716 Pig SwissProt: P63059 Rat Unigene: 724 Human Unigene: 265917 Mouse Unigene: 442648 Mouse Unigene: 11307 Rat
Product Picture	Sample: Stomach (Mouse) Lysate at 40 ug Primary: Anti-THRA1+2 (SL6222R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD Sample: Stomach (Mouse) Lysate at 40 ug Primary: Anti- THRA1+2 (SL6222R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 53 kD Paraformaldehyde-fixed, paraffin embedded (mouse testis tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (THRA1+2) Polyclonal Antibody, Unconjugated (SL6222R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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