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Product Name Nectin 3, Alexa Fluor 750 conjugated Chinese Name AF750标记的连接蛋白3抗体 Alias CD113; CDw113; DKFZP566B0846; FLJ90624; Nectin-3; Nectin3; Poliovirus receptor related 3; Poliovirus receptor related protein 3; Poliovirus receptor-related protein 3; PPR3; PRR3; PVRL 3; PVRL3; PVRL3_HUMAN; PVRR3. Research Area immunology Microbiology Bacteria and viruses Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Rabbit, ) Applications IF=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 55kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Nectin 3: 431-549/549 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Nectins are immunoglobulin-like adhesion molecules that interact with afadin. Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin-catenin system in epithelial cells. The nectin/PRR-family consists of four members, nectin-1, -2, -3 and -4. All the members of the nectin family have two or three slice variants. Nectin 3 is mainly expressed in testis and placental tissues and interacts in vivo with both long and short isoforms of afadin.
Function:
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Subunit:
Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT.
Subcellular Location:
Cell membrane; Single-pass membrane protein (Potential).
Tissue Specificity:
Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q9NQS3
Gene ID:
25945
Database links:Entrez Gene: 25945 Human
Entrez Gene: 58998 Mouse
Omim: 607147 Human
SwissProt: Q9NQS3 Human
SwissProt: Q9JLB9 Mouse
Unigene: 293917 Human
Unigene: 328072 Mouse
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