Product Name	Tomoregulin-1
Chinese Name	脑Tumour抑癌蛋白1抗体
Alias	Tomoregulin1; Tomoregulin 1; C9orf2; H 7365; H7365; TEFF 1; TEFF1; TMEFF 1; TMEFF1; TR 1; TR1; Transmembrane protein with EGF like and two follistatin like domains 1; TEFF1_HUMAN.
literatures	Specific References  (1)     |     SL6117R has been referenced in 1 publications. [IF=5] Bao, Dan, et al. "Tomoregulin-1 inhibits cardiac hypertrophy after pressure overload via TAK1-JNK pathways in mice." Disease Models & Mechanisms(2015): dmm-021303.  IHC-F ;  Mouse.   PubMed:26092120
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Tomoregulin-1: 65-160/380 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Tomoregulin-1 precursor is a single-pass type I membrane protein thought to be a tumor suppressor in brain cancers. Its expression is down-regulated in these tumors as compared to control brain tissues. In addition, it might also inhibit NODAL and BMP signaling during neural patterning. There are 2 isoforms produced by alternative splicing. Function: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. Subunit: May interact with ST14. Subcellular Location: Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Tissue Specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. Similarity: Belongs to the tomoregulin family. Contains 1 EGF-like domain. Contains 2 Kazal-like domains. SWISS: Q8IYR6 Gene ID: 8577 Database links: Entrez Gene: 100526694 Human Entrez Gene: 8577 Human Entrez Gene: 230157 Mouse Entrez Gene: 63845 Rat Omim: 603421 Human SwissProt: Q8IYR6 Human SwissProt: Q6PFE7 Mouse SwissProt: Q9QYV1 Rat Unigene: 598100 Human Unigene: 422686 Mouse Unigene: 162809 Rat

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