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Product Name TUSC1 Chinese Name 肺癌抑癌蛋白1抗体 Alias TSG 9; TSG9; Tumor suppressor candidate 1; Tumor suppressor candidate gene 1 protein; TUSC1_HUMAN. literatures Specific References (2) | SL6114R has been referenced in 2 publications.[IF=2.64] Kanda, Mitsuro, et al. "Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer." Journal of Surgical Oncology (2014). IHC-P ; Human.[IF=2.3] Shimizu, Dai, et al. "Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma." Oncology Reports. IHC-P ; Human.Research Area Tumour immunology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Pig, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TUSC1: 131-212/212 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
Tissue Specificity:
Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.
SWISS:
Q2TAM9
Gene ID:
286319
Database links:Entrez Gene: 286319 Human
Entrez Gene: 69136 Mouse
Omim: 610529 Human
SwissProt: Q2TAM9 Human
SwissProt: Q673H1 Mouse
Unigene: 26268 Human
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