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Product Name RUNX1T1 Chinese Name 周期素D相关蛋白抗体 Alias Acute myelogenous leukemia 1 translocation 1 cyclin D related; Acute myelogenous leukemia 1 translocation 1 protein; AML1T1; CBFA2T1; CDR; Core binding factor runt domain alpha subunit 2 translocated to 1; Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related; Cyclin D related; Cyclin D related protein; Eight twenty one protein; Eigth twenty one protein; ETO; ETO protein; MTG 8; MTG 8b; MTG8. MTG8 protein; MTG8b antibody Myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG 8; Protein MTG8; Runt related transcription factor 1 translocated to 1 (cyclin D related); Runt related transcription factor 1 translocated to 1; Runt related transcription factor 1 translocated to 1 cyclin D related; Zinc finger MYND domain containing protein 2; ZMYND 2; ZMYND2. Research Area Tumour Cell biology Chromatin and nuclear signals Signal transduction Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 66kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RUNX1T1/ETO: 431-530/604 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Subunit:
Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression.
Subcellular Location:
Nucleus.
Tissue Specificity:
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
Similarity:
Belongs to the CBFA2T family.
Contains 1 MYND-type zinc finger.
Contains 1 TAFH (NHR1) domain.
SWISS:
Q06455
Gene ID:
862
Database links:Entrez Gene: 862 Human
Entrez Gene: 12395 Mouse
Omim: 133435 Human
SwissProt: Q06455 Human
SwissProt: Q61909 Mouse
Unigene: 368431 Human
Unigene: 470961 Mouse
Unigene: 4909 Mouse
Unigene: 218117 Rat
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