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Product Name SESN3 Chinese Name Sestrin3抗体 Alias SESN3; SESN3_HUMAN; SEST3; Sestrin 3; Sestrin-3. literatures Specific References (2) | SL6100R has been referenced in 2 publications.[IF=5.168] Kosaka et al. Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer. (2017) Oncotarget. 8:87675-87683 IF(ICC) ; Human.[IF=5.14] Agata Wrońska. et al. Sestrins’ Expression in the Liver Is Not Altered by Short-Term Calorie Restriction in Young and Old Rats. Gerontology. ;:1-9 WB ; Rat.Research Area Tumour Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, Guinea Pig, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 54kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SESN3: 401-492/492 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Subcellular Location:
Widely expressed.
Similarity:
Belongs to the sestrin family.
SWISS:
P58005
Gene ID:
143686
Database links:Entrez Gene: 143686 Human
Entrez Gene: 75747 Mouse
Omim: 607768 Human
SwissProt: P58005 Human
SwissProt: Q9CYP7 Mouse
Unigene: 659934 Human
Unigene: 325126 Mouse
Unigene: 439776 Mouse
Product Picture Sample:
Cerebellum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti- SESN3 (SL6100R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kD
Observed band size: 52 kD
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