Product Name	SASH1
Chinese Name	Tumour抑制基因PEPE1抗体
Alias	PEPE 1; PEPE1; Proline glutamate repeat containing protein; Proline-glutamate repeat-containing protein; RP3 323M4.1; SAM and SH3 domain containing 1; SAM and SH3 domain containing protein 1; SAM and SH3 domain-containing protein 1; SASH 1; Sash1; SASH1_HUMAN.
literatures	Specific References  (3)     |     SL6099R has been referenced in 3 publications. [IF=7.035] Siyi Liu. et al. Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury. CNS NEUROSCI THER. 2022 Oct;:  WB ;  Rat.   PubMed:36286186 [IF=4.067] Cui HZ et al. SASH1 promotes melanin synthesis and migration via suppression of TGF-β1 secretion in melanocytes resulting in pathologic hyperpigmentation. International Journal of Biological Sciences. 2020; 16(7): 1264-1273.  IHC-P&WB ;  Human.   PubMed:doi: 10.7150/ijbs.38415 [IF=2.705] Ma C et al. Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells. Biochem Biophys Res Commun. 2019 Oct 15;518(2):325-330.  WB ;  Rat.   PubMed:31421824
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	137kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SASH1: 421-520/1247
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SASH1 is a 1247 amino acid protein that is significantly downregulated in the majority of primary breast tumor tissues, breast cancer cell lines, lung and thyroid tumors, as well as in certain colon carcinomas. It has been hypothesized that its expression is suppressed not due to mutation of the SASH1 gene, but instead via other mechanisms, such as promoter methylation. As a member of the SH3-domain containing expressed in lymphocytes (SLY1) gene family, SASH1 contains two sterile α modules (SAMs) and one Src homology-3 (SH3) domain, motifs that are predominantly found in adaptors, scaffold proteins and signaling molecules. Downregulation of SASH1 expression correlates with the formation of distant metastasis and is considered a negative prognostic parameter for patient survival. Function: May have a role in a signaling pathway. Could act as a tumor suppressor. Tissue Specificity: Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Similarity: ontains 2 SAM (sterile alpha motif) domains. Contains 1 SH3 domain. SWISS: O94885 Gene ID: 23328 Database links: Entrez Gene: 23328 Human Entrez Gene: 70097 Mouse Omim: 607955 Human SwissProt: O94885 Human SwissProt: P59808 Mouse Unigene: 193133 Human Unigene: 338275 Mouse

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