Product Name	Rho GTPase activating protein 29
Chinese Name	Rho GTP酶激活蛋白29抗体
Alias	ARHGAP 29; ARHGAP29; ARHGAP29 protein; MGC166097; PARG 1; PARG1; PTPL1 associated RhoGAP 1; PTPL1-associated RhoGAP protein 1; RHG29_HUMAN; Rho GTPase acti ating protein 29; Rho GTPase acti ating protein 29 isoform CRA_a; Rho GTPase acti ating protein 29 isoform CRA_b; Rho GTPase-acti ating protein 29; Rho-type GTPase-acti ating protein 29.
literatures	Specific References  (1)     |     SL6098R has been referenced in 1 publications. [IF=4.074] Zhang M et al. Proteomic analysis reveals proteins and pathways associated with lactation in bovine mammary epithelial cell-derived exosomes. J Proteome Res . 2020 Aug 7;19(8):3211-3219.  WB ;  Cow.   PubMed:32506918
Research Area	Tumour  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	142kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PARG1: 301-400/1261
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Rho GTPase activating protein 29 is a GTPase activator for the Rho-type GTPases. It converts them to an inactive GDP-bound state. It has strong activity toward RHOA and weaker activity toward RAC1 and CDC42. It also may act as a specific effector of RAP2A to regulate Rho. There are two named isoforms produced by alternative splicing. Rho GTPase activating protein 29 is widely expressed; highly expressed in skeletal muscle and heart; expressed at intermediate level in placenta, liver and pancreas; weakly expressed in brain, lung and kidney. Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. Subunit: Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain. Interacts with RASIP1 (By similarity). Tissue Specificity: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain. SWISS: Q52LW3 Gene ID: 9411 Database links: Entrez Gene: 9411 Human Entrez Gene: 214137 Mouse Omim: 610496 Human SwissProt: Q52LW3 Human SwissProt: Q8CGF1 Mouse Unigene: 483238 Human Unigene: 229287 Mouse

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