Product Name	XAB2
Chinese Name	XAB2蛋白抗体
Alias	0610041O14Rik; adapter protein ATH 55; Adapter protein ATH-55; Ath55; AV025587; Crn related protein kim1; crn-related protein kim1; DKFZp762C1015; HCNP; HCNP protein; HCRN; KIAA1177; NTC90; PP3898; Pre-mRNA-splicing factor SYF1; Protein HCNP; RNA splicing factor; SYF1; SYF1 homolog; SYF1 homolog, RNA splicing factor; SYF1_HUMAN; Xab2; XPA binding protein 2; XPA-binding protein 2.
literatures	Specific References  (1)     |     SL6080R has been referenced in 1 publications. [IF=4.966] Shuiming Guo. et al. Pre‐ischemic renal lavage protects against renal ischemia‐reperfusion injury by attenuation of local and systemic inflammatory responses. Faseb J. 2020 Dec;34(12):16307-16318  WB ;  Rat.   PubMed:33089923
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PBP/HCNP: 65-160/855
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	XAB2 protein (XPA binding protein 2) was first identified through its interaction with XPA, a key factor in nucleotide excision repair pathways. XAB2 therefore appears to be involved in transcription coupled DNA repair and transcription. Immunoprecipitation experiments have also demonstrated that a fraction of XAB2 interacts with the transcription coupled repair specific proteins CSA and CSB as well as with RNA polymerase II. Microinjection experiments with XAB2 antibodies resulted in the inhibition of both transcription coupled repair and transcription. Function: Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Subunit: Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Subcellular Location: Nucleus (By similarity). Note=Detected in the splicing complex carrying pre-mRNA (By similarity). Similarity: Belongs to the crooked-neck family. Contains 14 HAT repeats. SWISS: Q9HCS7 Gene ID: 56949 Database links: Entrez Gene: 56949 Human Entrez Gene: 67439 Mouse Entrez Gene: 100525328 Pig Entrez Gene: 245976 Rat Omim: 610850 Human SwissProt: Q9HCS7 Human SwissProt: Q9DCD2 Mouse SwissProt: Q99PK0 Rat Unigene: 9822 Human Unigene: 23739 Mouse Unigene: 24921 Rat

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