Product Name	MTUS1
Chinese Name	微管相关Tumour抑制因子1 抗体
Alias	Angiotensin II type 2 receptor interacting protein; AT2 receptor interacting protein; AT2R binding protein; ATIP; ATIP1; Erythroid differentiation related; FLJ14295; GK 1; GK1; KIAA1288; Microtubule associated tumor suppressor 1; Mitochondrial tumor suppressor 1; Mitochondrial tumor suppressor gene 1; MP 44; MP44; MTSG 1; MTSG1; MTUS 1; Transcription factor MTSG1; MTUS1_HUMAN.
literatures	Specific References  (2)     |     SL6076R has been referenced in 2 publications. [IF=6.126] Nikhil Ranjan. et al. The Tumor Suppressor MTUS1/ATIP1 Modulates Tumor Promotion in Glioma: Association with Epigenetics and DNA Repair. Cancers. 2021 Jan;13(6):1245  WB,IHC ;  Human.   PubMed:33809019 [IF=3.448] Chen ZZ et al. Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. Life Sci. 2019 Nov 20;240:117085.  IHC-P&WB ;  Rat.   PubMed:31759042
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	141kDa
Cellular localization	The cell membrane Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MTUS1: 1151-1270/1270
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]. Function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Subunit: Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules. Subcellular Location: Mitochondrion. Golgi apparatus (By similarity). Cell membrane (By similarity). Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin-II (By similarity). Isoform 1: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. Tissue Specificity: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. DISEASE: Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The gene represented in this entry may be involved in disease pathogenesis. Similarity: Belongs to the MTUS1 family. SWISS: Q9ULD2 Gene ID: 57509 Database links: Entrez Gene: 482896 Dog Entrez Gene: 57509 Human Entrez Gene: 102103 Mouse Entrez Gene: 306487 Rat Omim: 609589 Human SwissProt: Q9ULD2 Human SwissProt: Q5HZI1 Mouse SwissProt: Q6IMY1 Rat Unigene: 7946 Human
Product Picture	Sample: Uterus (mouse) Lysate at 40 ug Primary: Anti- MTUS1/Angiotensin II Type 2 Receptor (SL6076R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 141 kD Observed band size: 135 kD Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MTUS1 Angiotensin II Type 2 Receptor) Polyclonal Antibody, Unconjugated (SL6076R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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