Product Name	FGFR5
Chinese Name	成纤维细胞生长因子受体5抗体
Alias	FGF homologous factor receptor; FGF receptor like protein 1; FGFR 5; FGFR like protein; FGFR5; FGFRL1; FHFR; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor like 1; FGRL1_HUMAN.
literatures	Specific References  (3)     |     SL6049R has been referenced in 3 publications. [IF=6.205] Cheng S et al. Comparative analysis of Longissimus dorsi tissue from two sheep groups identifies differentially expressed genes related to growth, development and meat quality. Genomics. 2020 Sep;112(5):3322-3330.  WB ;  Sheep.   PubMed:32534014 [IF=5.78] Xiongjie Fu. et al. Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice. 2021 Feb 04  IF ;  Mouse.   PubMed:33539006 [IF=4.486] Wang L et al. Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. J Cell Mol Med. 2020 Jun;24(11):6324-6339.  WB ;  Human.   PubMed:32396269
Research Area	Cell biology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FGFR5/FGFRL1: 231-330/504
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found. Function: UniProtKB/Swiss-Prot: Q8N441.1 FASTA Graphics Go to: LOCUS FGRL1_HUMAN 504 aa linear PRI 01-MAY-2013 DEFINITION RecName: Full=Fibroblast growth factor receptor-like 1; Short=FGF receptor-like protein 1; AltName: Full=FGF homologous factor receptor; AltName: Full=FGFR-like protein; AltName: Full=Fibroblast growth factor receptor 5; Short=FGFR-5; Flags: Precursor. Subunit: Interacts with FGF2 with a low affinity. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q8N441 Gene ID: 53834 Database links: Entrez Gene: 53834 Human Entrez Gene: 116701 Mouse Entrez Gene: 360903 Rat Omim: 605830 Human SwissProt: Q8N441 Human SwissProt: Q91V87 Mouse SwissProt: Q7TQM3 Rat Unigene: 193326 Human Unigene: 35691 Mouse Unigene: 44953 Rat

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