Product Name	phospho-CD32 (Tyr292)
Chinese Name	磷酸化CD32B抗体
Alias	CD32B(phospho Y292); CD32B; FCGR2B; IGFR2; Lym 1; CD32 antigen; CDw32; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor; Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for; Fc gamma receptor IIB; Fc gamma RII; Fc gamma RIIB; Fc-gamma RII; Fc-gamma RII-b; Fc-gamma-RIIb; FCG2; FCG2B_HUMAN; Fcgr2; FCRII; FcRII-b; IgG Fc receptor II beta; IgG Fc receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II; Low affinity immunoglobulin gamma Fc region receptor II-b; Ly-17; Lymphocyte antigen 17.
literatures	Specific References  (4)     |     SL6031R has been referenced in 4 publications. [IF=4.784] Wan B et al. Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction. Int J Biol Macromol. 2019 Jul 5;138:198-206.  WB ;  Monkey.   PubMed:31284005 [IF=4.366] Caparrós E et al. Liver Sinusoidal Endothelial Cells Contribute to Hepatic Antigen-Presenting Cell Function and Th17 Expansion in Cirrhosis. Cells. 2020 May 15;9(5):1227.  FCM ;  Rat.   PubMed:32429209 [IF=2.776] Liu Y et al. IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma. PLoS One. 2019 Sep 27;14(9):e0222999.  IHC-P&WB&FCM ;  Mouse.   PubMed:31560714 [IF=2.423] Williams V et al. Fc-gamma receptor expression profile in a North-Indian cohort of pediatric-onset systemic lupus erythematosus: An observational study. (2018)International Journal of Rheumatic Diseases. Nov 6.  FCM ;  Human.   PubMed:30399647
Product Type	Phosphorylated anti
Research Area	Cell biology  immunology  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	31kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human CD32B around the phosphorylation site of Tyr291: IT(p-Y)SL
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. Subunit: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. Post-translational modifications: Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like). SWISS: P31994 Gene ID: 2213 Database links: Entrez Gene: 2213 Human SwissProt: P31994 Human
Product Picture	Sample: 293T Cell (Human) Lysate at 40 ug Primary: Anti-phospho-CD32B(Tyr292) (SL6031R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 36 kD Paraformaldehyde-fixed, paraffin embedded (Mouse placenta); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-CD32B(Tyr292)) Polyclonal Antibody, Unconjugated (SL6031R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. phosphopeptide non phosphopeptide

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