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Product Name LETMD1 Chinese Name 宫颈癌原癌基因2抗体 Alias LETM1 domain-containing protein 1; Cervical cancer 1 proto-oncogene protein p40; Cervical cancer proto-oncogene 2 protein; HCCR-1; HCRR-2; LTMD1_HUMAN; HCCR 2; HCCR2. Research Area Tumour immunology TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 40kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HCCR2/LETMD1: 21-120/360 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011].
Function:
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
Subunit:
Interacts with BRI3BP.
Subcellular Location:
Mitochondrion outer membrane; Single-pass membrane protein.
Tissue Specificity:
Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
Similarity:
Contains 1 LETM1 domain.
SWISS:
Q6P1Q0
Gene ID:
25875
Database links:Entrez Gene: 25875 Human
Entrez Gene: 68614 Mouse
SwissProt: Q6P1Q0 Human
SwissProt: Q924L1 Mouse
Unigene: 655272 Human
Unigene: 275272 Mouse
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