Product Name	PGRMC
Chinese Name	孕激素受体膜相关元件抗体
Alias	HPR6.6; Membrane associated progesterone receptor component 1; y mPR; PGRMC1; PGRMC 1; PGRMC-1; Progesterone receptor membrane component 1.
Research Area	Tumour  Cardiovascular  immunology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Pig, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PGRMC: 75-170/195
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PGRMC1 is a progesterone receptor component of 195 aa with a 26 residue N terminal hydrophobic region and no N terminal glycosylation site. It has an overall homology of 50% with PGRMC2 but their C terminal regions have a 68% homology, including a highly conserved 58 residue sequence.PGRMC1 is a heme bind proteins that is up-regulated in several cancers. In breast tumors, PGRMC1 is associated with hypoxia estrogen receptor-negative status. PGRMC1 is also shown to stimulate AKT phosphorylation and is known to stabilise the EGFR receptor tyrosine kinase. Function: Receptor for progesterone (By similarity). Subcellular Location: Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Tissue Specificity: Widely expressed, with highest expression in liver and kidney. Similarity: Belongs to the cytochrome b5 family. MAPR subfamily. Contains 1 cytochrome b5 heme-binding domain. SWISS: O00264 Gene ID: 10857 Database links: Entrez Gene: 317706 Cow Entrez Gene: 10857 Human Entrez Gene: 53328 Mouse Entrez Gene: 396946 Pig Entrez Gene: 291948 Rat Omim: 300435 Human SwissProt: Q17QC0 Cow SwissProt: O00264 Human SwissProt: O55022 Mouse SwissProt: Q95250 Pig SwissProt: P70580 Rat Unigene: 90061 Human Unigene: 9052 Mouse Unigene: 102356 Rat
Product Picture	Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PGRMC Polyclonal Antibody, Unconjugated(SL5922R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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