Product Name	ADAMTS8
Chinese Name	整合素样金属蛋白酶与凝血酶8型抗体
Alias	A disintegrin and metalloproteinase with thrombospondin motifs 8; ADAMTS 8; METH 2; METH 8; METH8; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 8; A disintegrin like and metalloprotease with thrombospondin type 1 motif 8; ADAM metallopeptidase with thrombospondin type 1 motif 8; ADAM TS 8; ADAM TS8; METH2; ATS8_HUMAN.
literatures	Specific References  (3)     |     SL5859R has been referenced in 3 publications. [IF=4.927] Pan Xu. et al. MOBT Alleviates Pulmonary Fibrosis through an lncITPF–hnRNP-l-Complex-Mediated Signaling Pathway. MOLECULES. 2022 Jan;27(16):5336  WB ;  Mouse, Human.   PubMed:36014574 [IF=3.575] Yutian Zhang. et al. ADAMTS8 inhibited lung cancer progression through suppressing VEGFA. Biochem Bioph Res Co. 2022 Apr;598:1  WB ;  Human.   PubMed:35149432 [IF=1.13] Musa Tatar. et al. Expression of ADAMTS 1-4-8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester. ANAT HISTOL EMBRYOL. 2023 Apr;:  IHC ;  Rat.   PubMed:37014320
Research Area	Tumour  Cell biology  immunology  Signal transduction  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	74kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ADAMTS8: 541-640/889
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. A member of the metalloproteinase family containing disintegrin like domains (ADAMs), the function of ADAMTS8 is still poorly understood. ADAMTS8 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active on a range of substrates. ADAMTS8 is inhibited by the endogenous MMP inhibitors, TIMP1, 2, 3 and 4, but most efficiently by TIMP3. In addition to the metalloprotease domain, ADAMTS8 has a propeptide domain, a Prohormone Convertase (PC, furin) cleavage site, a cysteine rich domain and thrombospondin 1 like domains. Function: Has anti-angiogenic properties. Subcellular Location: Secreted, extracellular space, extracellular matrix (By similarity). Tissue Specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney. Post-translational modifications: The precursor is cleaved by a furin endopeptidase (By similarity). Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 2 TSP type-1 domains. SWISS: Q9UP79 Gene ID: 11095 Database links: Extracellular matrix蛋白

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